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Localized hydrogel delivery of photoactivatable mRNA lipid nanoparticles and hyaluronidase for postoperative TNBC immunotherapy

Academic source · International journal of biological macromolecules

Source published: 2026-09-06

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

An injectable hydrogel co-delivered hyaluronidase and light-responsive nanoparticles carrying IL-12 and GM-CSF mRNAs. The design combined stromal remodeling, local retention, and photoactivated intracellular delivery. In a postoperative mouse breast-cancer model, treatment reduced recurrence and altered local and systemic immune responses. The multiple-component system remains experimental, with light access, long-term safety, and clinical feasibility requiring further work.

Why this paper is included

Integrates extracellular and intracellular delivery strategies after surgery; a mouse recurrence model and short-term safety checks cannot establish clinical recurrence prevention.

The interpretation above is analysis, not a conclusion attributed to the original source.

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mRNA / LNP

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