The current landscape of mRNA therapy and the strategies for mRNA purification and dsRNA removal
Academic source · Journal of Biomedical Science
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
This review examines mRNA therapy and impurity control during in vitro transcription, focusing on purification strategies and double-stranded RNA removal. It compares detection and separation approaches with attention to RNA integrity, recovery, and manufacturing feasibility. Construct-specific differences and analytical limitations complicate direct comparisons; the review does not establish a universal acceptable dsRNA limit for every product.
Why this paper is included
Useful for selecting purification and impurity assays; product specifications still require validated measurement capabilities and evidence linking impurities to biological risk.
The interpretation above is analysis, not a conclusion attributed to the original source.
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