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Circular RNA Delivery In Vitro and In Vivo Using Doubly Branched Aminoethoxy-Functionalized Ionizable Lipid Nanoparticles

Academic source · Journal of the American Chemical Society

Source published: 2026-10-10

Site published: 2026-11-03 · Updated: 2026-11-03

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Findings and limitations Industry implications Related developments

What the paper reports

A study designed ionizable lipids specifically for circular RNA, whose topology differs from linear mRNA. Lead lipid iL-19 combined aminoethoxy head groups with doubly branched tails and improved protein expression after intramuscular delivery in mice relative to several benchmark lipids. The results establish preclinical design principles, not clinical superiority.

Why this paper is included

Circular RNA programs may benefit from dedicated lipid optimization instead of assuming formulations developed for linear RNA will transfer unchanged.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

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