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In Vivo Blood Kinetics and Transcript Integrity of Three mRNA–Lipid Nanoparticle Vaccines in Humans

Academic source · ACS Nano

Source published: 2026-10-15

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

Serial blood samples from 73 vaccine recipients were analyzed using ddPCR for total and long-range-linked mRNA and LC-MS for ionizable lipids. RNA and lipid decay differed across three vaccine platforms. Cohorts differed in dose, vaccination history, and sampling schedules. Detecting circulating RNA fragments does not by itself establish continued protein expression, clinical toxicity, or comparative vaccine effectiveness.

Why this paper is included

Provides human benchmarking for RNA and lipid measurements while distinguishing total fragments, intact transcripts, functional exposure, and clinical outcomes.

The interpretation above is analysis, not a conclusion attributed to the original source.

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