An inherent T cell-activating mRNA delivery carrier for in vivo CAR T generation
Qiannan Cao; Yingli Yao; Wenming Zheng; Hongqian Liu; Mingxia Jiang; Dayang Xie; Siting Zhang; Pijun Su; Huilin Yuan; Xiaoyuan Chen; Huapan Fang; Huayu Tian
Nature Materials ·
DOI: 10.1038/s41563-026-02675-7
Research guide
The authors report a polymer–lipid carrier that combines mRNA delivery with T-cell activation without an antibody targeting ligand. The study links the carrier to metabolic signaling and evaluates CAR expression and activity in preclinical cancer and fibrosis models. These findings do not establish safety or benefit in patients.
Potential research relevance
Connects delivery and cell biology while preserving the boundary between preclinical activity and human evidence.
Guide basis: Original journal abstract and bibliographic metadata. No expert sign-off or citation count is claimed.