Structure Revision of the Lomaiviticins
Academic source · Journal of the American Chemical Society
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
MicroED analysis of lomaiviticin C prompted revision of its molecular connectivity and stereochemical assignments. High-field NMR and computational analysis supported the revised interpretation, with implications for related lomaiviticins. This is a natural-product structure-elucidation landmark rather than a pharmaceutical-polymorph study, demonstrating the value of complementary methods when complex, sparsely protonated molecules resist confident NMR assignment.
Why this paper is included
A strong example of structure correction rather than confirmation, relevant to discovery chemistry while retaining its natural-product and non-polymorph scope.
The interpretation above is analysis, not a conclusion attributed to the original source.
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