Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED
Academic source · Advanced Biology
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Researchers determined two polymorphic crystal structures of the oral macrocyclic drug paritaprevir within the same MicroED experiment. The forms differed in macrocycle and substituent conformations. Docking suggested that one conformation could fit the viral protease binding pocket. The structural and computational results inform conformational analysis but do not establish a difference in clinical performance between polymorphs.
Why this paper is included
A direct macrocyclic-drug example connecting polymorphism with molecular conformation, useful for solid-form selection and interpretation of structural models.
The interpretation above is analysis, not a conclusion attributed to the original source.
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