Structural Elucidation and Absolute Stereochemistry for Pharma Compounds Using MicroED
Academic source · Organic Letters
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
This industry-linked evaluation examined 30 samples from Amgen process and medicinal chemistry groups. Fifteen crystal structures were elucidated using 40 hours of microscope time. For the chiral compounds whose structures were solved, dynamical refinement assigned the correct absolute stereochemistry. The study provides an observed sample-set outcome rather than a universal success rate for pharmaceutical materials.
Why this paper is included
A practical industrial benchmark for feasibility, instrument time, and absolute-configuration workflows, with an unusually useful denominator for interpreting success claims.
The interpretation above is analysis, not a conclusion attributed to the original source.
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