From formulation to structure: 3D electron diffraction for the structure solution of a new indomethacin polymorph from an amorphous solid dispersion
Academic source · IUCrJ
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
3D electron diffraction resolved the structure of the ninth reported indomethacin polymorph, designated sigma, from crystals found within an amorphous solid dispersion. Subsequent experiments produced the same form by solvent evaporation. The work demonstrates structure determination directly from a formulation-related sample containing an excipient; it does not establish improved dissolution or clinical performance for the new form.
Why this paper is included
A highly relevant formulation case linking unexpected crystallinity in an ASD with definitive structure determination and a follow-up crystallization route.
The interpretation above is analysis, not a conclusion attributed to the original source.
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MicroED structure determination Pharmaceutical solid state Formulation Development & Manufacturing