GROND preprint adds dynamical corrections to standard electron crystallography workflows
Academic source · bioRxiv
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
An October 27 preprint introduces GROND, an open-source tool that inserts dynamical scattering corrections between conventional electron diffraction processing and refinement. Tests across six structures improved refinement residuals and revealed previously unmodeled hydrogen atoms in small molecules. The work has not been peer reviewed, and performance on pharmaceutical samples needs separate validation.
Why it may matter
If independently validated, the approach could make dynamical refinement easier to adopt and improve structural information extracted from small-molecule diffraction data.
The interpretation above is analysis, not a conclusion attributed to the original source.
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