Microcrystal electron diffraction (MicroED) structure determination of a mechanochemically synthesized co-crystal not affordable from solution crystallization
Academic source · CrystEngComm
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
MicroED determined a powder-derived cocrystal of 2-aminopyrimidine and succinic acid prepared by solid-state grinding. The mechanically generated phase was not accessible through the solution-crystallization route examined. This is a model organic cocrystal rather than an API efficacy study, illustrating how electron diffraction can characterize crystal-engineering products without first recreating them as large solution-grown crystals.
Why this paper is included
Relevant to mechanochemical solid-form development, while the model-system scope should remain clear when extrapolating to pharmaceutical cocrystal programs.
The interpretation above is analysis, not a conclusion attributed to the original source.
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