Rapid Structure Determination of Ranitidine Hydrochloride API in Two Crystal Forms Using Microcrystal Electron Diffraction
Academic source · Chemical and Pharmaceutical Bulletin
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Researchers used MicroED to determine the crystal structures of ranitidine hydrochloride Forms 1 and 2. The resulting structures agreed with previously reported X-ray diffraction structures. The work presents a focused pharmaceutical proof of applicability for small-quantity or microcrystalline API samples, while retaining the need to control crystal form, hydration, and residual solvents through complementary quality assessments.
Why this paper is included
A straightforward API polymorph comparison that helps readers evaluate MicroED against established X-ray structures rather than relying solely on novel discoveries.
The interpretation above is analysis, not a conclusion attributed to the original source.
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