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Structural Analysis of Active Pharmaceutical Ingredients in Tablets Using 3D ED/MicroED

Academic source · Molecular Pharmaceutics

Source published: 2025-04-17

Site published: 2026-11-03 · Updated: 2026-11-03

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What the paper reports

The study examined API crystals directly in Allegra, Clarith, and Ibrance tablets using selected-area 3D ED/MicroED. Fexofenadine hydrochloride Form I and clarithromycin Form II retained their polymorphs, while palbociclib Form A showed slight lattice shrinkage. The results demonstrate formulation-level structural analysis and emphasize that a lattice change and a new polymorph are different findings.

Why this paper is included

Direct tablet measurements make this a particularly useful reference for formulation development, manufacturing comparisons, and investigating API form changes in finished products.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

MicroED structure determination Pharmaceutical solid state Formulation Development & Manufacturing

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