The cryo-EM method microcrystal electron diffraction (MicroED)
Academic source · Nature Methods
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
This review explains MicroED and compares its role with other structure-determination methods. It surveys example structures and practical considerations for prospective users, including the progression from specimen preparation to diffraction acquisition and analysis. Its value for pharmaceutical readers is methodological orientation across sample classes, rather than evidence that a specific API screening workflow has been validated.
Why this paper is included
A clear starting point for teams adopting MicroED, helping them distinguish general method capabilities from compound-specific validation needs.
The interpretation above is analysis, not a conclusion attributed to the original source.
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