An Overview of Microcrystal Electron Diffraction (MicroED)
Academic source · Annual Review of Biochemistry
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
This review introduces the development and scope of MicroED, from small molecules and peptides to proteins and larger complexes. It explains how nanocrystalline samples extend crystallographic opportunities and summarizes the method’s trajectory. Its value for pharmaceutical materials is conceptual orientation; readers should use dedicated API studies to evaluate solid-form identification and industrial performance.
Why this paper is included
A broad entry point for understanding the technique before moving to pharmaceutical polymorph, formulation, and stereochemistry case studies.
The interpretation above is analysis, not a conclusion attributed to the original source.
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