Phase Identification and Discovery of an Elusive Polymorph of Drug‐Polymer Inclusion Complex Using Automated 3D Electron Diffraction
Academic source · Angewandte Chemie International Edition
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
An automated low-dose 3D electron diffraction workflow identified six phases in a melt-crystallized griseofulvin–polyethylene glycol system. More than 230 datasets were collected and processed in three days. The researchers resolved known drug polymorphs and inclusion complexes alongside an elusive new inclusion-complex phase, then related the two inclusion-complex polymorphs to their structural stability differences.
Why this paper is included
A strong pharmaceutical screening case showing how automated crystal-by-crystal analysis can uncover minor phases in complex, beam-sensitive crystallization products.
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