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Enlicitide analysis examines LDL lowering across kidney function groups

Industry reporting · Pharmacy Times

Source published: · Event / reporting date: 2026-10-22

Site published: 2026-11-03 · Updated: 2026-11-03

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Findings and limitationsIndustry implicationsRelated developments

What changed

A Kidney Week report described pooled CORALreef trial findings for oral PCSK9 inhibitor enlicitide across kidney function groups. Participants with estimated glomerular filtration rates below 60 had a 65.9% placebo-adjusted LDL cholesterol reduction at Week 24. This subgroup analysis addresses lipid lowering; it does not establish fewer cardiovascular events, which require dedicated outcomes evidence.

Why it may matter

Renal subgroup evidence helps define practical development questions for oral macrocycles, but biomarker improvements should remain distinct from proven cardiovascular outcomes.

The interpretation above is analysis, not a conclusion attributed to the original source.

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