Date check: ACS gives October 5, 2026 as first online publication. PubMed lists November 2 for volume 23, issue 11, pages 5318–5326. This record retains the first-publication date and DOI. Author affiliations include the University of Cambridge and GSK.
Formulations at the Nanoscale: Multi-dimensional Electron Diffraction of Long-Acting Injectable, Cabotegravir
Academic source · Molecular Pharmaceutics / American Chemical Society
Source published: · Event / reporting date: 2026-10-05
Site published: 2026-11-03 · Updated: 2026-11-04
Explore this article with AI
Ask AI ↗This source is linked automatically. Choose a question to get started.
What the paper reports
This study applied multidimensional electron diffraction to cabotegravir nanocrystals within a long-acting injectable formulation. 3D electron diffraction confirmed a structure consistent with the known X-ray model, while imaging and diffraction linked particle shape to crystal structure and revealed dislocations. The results describe nanoscale structural features that may guide formulation work; improved product performance was not demonstrated.
Why this paper is included
A strong finished-formulation example connecting crystal structure, morphology, and defects in an injectable nanocrystal system rather than studying isolated API powder alone.
The interpretation above is analysis, not a conclusion attributed to the original source.
Read the original source ↗Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections
MicroED structure determination Formulation Development & Manufacturing