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Icotrokinra Phase 2 ulcerative colitis publication details responses and testing limits

Academic source · New England Journal of Medicine / Johnson & Johnson

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Site published: 2026-11-03 · Updated: 2026-11-03

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Findings and limitationsIndustry implicationsRelated developments

What changed

The 252-participant ANTHEM-UC Phase 2b publication found all three icotrokinra doses superior to placebo for week-12 clinical response. Remission was 30% versus 11% at 400 mg. The 200 mg remission comparison did not meet significance, stopping formal downstream testing under the prespecified sequence. These results do not establish approval for ulcerative colitis.

Why it may matter

Adds randomized evidence for oral treatment of intestinal inflammation while highlighting multiplicity limits and the distinction between trial results and approval.

The interpretation above is analysis, not a conclusion attributed to the original source.

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