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Amphista doses first patient with DCAF16-mediated BRD9 degrader AMX-883

Company / institutional announcement · Amphista Therapeutics

Source published: 2026-10-12

Site published: 2026-11-03 · Updated: 2026-11-03

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What changed

Amphista announced the first patient dose in BRAMLIE, a Phase 1 study of AMX-883 in acute myeloid leukemia and high-risk myelodysplastic syndrome. The oral candidate recruits DCAF16 to degrade BRD9. The study will evaluate safety, pharmacokinetics, and preliminary activity, moving a non-cereblon, non-VHL degradation approach beyond preclinical models and into patients.

Why it may matter

Clinical entry creates an important test for alternative E3 recruitment, while safety, tolerability, and patient benefit remain to be demonstrated.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Protein degradation / PROTAC

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