BIOTECH ASSISTANT / FIELD NOTES

Circle raises $92.5 million Series E for oral cyclin D1 macrocycle development

Company / institutional announcement · Circle Pharma

Source published: 2026-09-16

Site published: 2026-11-03 · Updated: 2026-11-03

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Findings and limitations Industry implications Related developments

What changed

Circle Pharma raised $92.5 million in Series E financing led by The Column Group, with investors including Eli Lilly. Proceeds prioritize CID-165, an oral macrocyclic cyclin D1 RxL inhibitor planned to enter clinical development in the first quarter of 2027, and support the broader pipeline. Reported CID-165 antitumor activity remains preclinical.

Why it may matter

Shows investment in oral macrocycles targeting intracellular interactions; financing and preclinical activity do not substitute for human evidence.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Prepared through Biotech Assistant’s automated research workflow. Editorial standards and corrections

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