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Related oral peptide reference: Ascletis reports preclinical PK data for once-weekly oral peptides

Company / institutional announcement · Ascletis Pharma (company release via PR Newswire)

Source published: 2026-10-20

Site published: 2026-11-03 · Updated: 2026-11-03

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Findings and limitations Industry implications Related developments

What changed

Ascletis reported that ASC36o, an oral amylin receptor agonist tablet, had an approximately seven-day half-life and 6%–8% oral bioavailability in nonhuman primates. The company said a US Phase 1 study was underway, with human PK results expected by year-end 2026. The quantitative findings are preclinical and do not yet establish once-weekly oral dosing in humans.

Why it may matter

Research perspective: Human exposure, variability, and food effects will be key tests of the delivery platform. This is an oral peptide delivery development, rather than a confirmed oral cyclic peptide program.

The interpretation above is analysis, not a conclusion attributed to the original source.

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Oral cyclic peptides Formulation Development & Manufacturing

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