Microcrystal electron diffraction in macromolecular and pharmaceutical structure determination
Academic source · Drug Discovery Today: Technologies
Source published:
Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Clabbers and Xu review the properties of electron diffraction and early MicroED developments relevant to pharmaceutical chemistry and structural biology. The discussion spans small-molecule structure determination, fragment screening, and structure-guided discovery. It is a historical perspective on opportunities and limitations, rather than new experimental proof of performance across a pharmaceutical sample collection.
Why this paper is included
An early pharmaceutical-facing review that helps explain why MicroED complements existing structural methods rather than replacing every crystallographic approach.
The interpretation above is analysis, not a conclusion attributed to the original source.
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