Polyethylene Glycol-Assisted Melt Crystallization of Two New Piroxicam Polymorphs Revealed by 3D Electron Diffraction
Academic source · Crystal Growth & Design
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Two previously unreported piroxicam polymorphs, Forms VIII and IX, emerged through polyethylene glycol-assisted melt crystallization. Their crystal structures were determined by 3D electron diffraction. Comparing the newly solved Form VIII with known Form IV allowed discussion of how differences in intermolecular hydrogen bonding contribute to melting behavior. The study concerns laboratory solid forms rather than validated drug-product performance.
Why this paper is included
Illustrates how polymer-assisted screening and 3D ED can jointly expand a well-studied API’s polymorph landscape and explain thermal-property differences.
The interpretation above is analysis, not a conclusion attributed to the original source.
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