Organic pigment benchmark evaluates XRPD as a prescreen for 3D electron diffraction
Academic source · Zeitschrift für Kristallographie – Crystalline Materials
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Site published: 2026-11-03 · Updated: 2026-11-03
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What changed
Researchers compared laboratory powder X-ray diffraction with 3D electron diffraction outcomes for 29 samples spanning 17 organic pigments. XRPD-derived domain size was the most useful screening indicator; structure solution succeeded above approximately 31 nanometers and failed below that value in this sample set. The threshold is empirical and should not be generalized to every pharmaceutical solid.
Why it may matter
XRPD prescreening could help laboratories prioritize instrument time, but pharmaceutical teams should establish sample-specific criteria before adopting the reported size threshold.
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