3D electron diffraction for structure determination of small‐molecule nanocrystals: A possible breakthrough for the pharmaceutical industry
Academic source · WIREs Nanomedicine and Nanobiotechnology
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
This review examines three-dimensional electron diffraction for beam-sensitive small-molecule nanocrystals, with a pharmaceutical-industry perspective. It discusses experimental strategies, diffraction completeness, dynamical scattering, and structural applications that extend beyond conventional large-crystal requirements. It provides a methods-oriented framework for interpreting published demonstrations; it does not establish a universal preparation method or replace sample-specific feasibility assessment.
Why this paper is included
Helps pharmaceutical researchers compare related electron-diffraction methods and evaluate experimental limitations before selecting an instrument, collaborator, or service workflow.
The interpretation above is analysis, not a conclusion attributed to the original source.
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