The CryoEM Method MicroED as a Powerful Tool for Small Molecule Structure Determination
Academic source · ACS Central Science
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Site published: 2026-11-03 · Updated: 2026-11-03
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What the paper reports
Researchers demonstrated atomic-resolution structure determination of small organic molecules from nanocrystals present in ordinary powders, using minimal specimen preparation. The study included pharmaceutical and natural-product examples and showed that individual compounds could be analyzed from a mixed specimen. It established a practical route around the need to grow crystals large enough for conventional single-crystal X-ray diffraction.
Why this paper is included
A foundational demonstration of powder-to-structure analysis; its examples should not be interpreted as a universal success rate for pharmaceutical samples.
The interpretation above is analysis, not a conclusion attributed to the original source.
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