COMPANY RESEARCHThe website lists a selective heterobifunctional p300 degrader as IND-enabling. PVTX-321 ER and PVTX-405 IKZF2 molecular glues are ready for GLP toxicology scale-up.
SK Inc.’s $200 million equity investment in 2021 is historical. A separate parent-company capital contribution in 2026 is not combined with it.
Profile review: 2026-11-04 · Fields retain their individual source dates. Undisclosed values are not zero; early or historical events do not establish the latest financing. Awards and acquisitions are distinguished from equity rounds.
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The website lists a selective heterobifunctional p300 degrader as IND-enabling. PVTX-321 ER and PVTX-405 IKZF2 molecular glues are ready for GLP toxicology scale-up.
The website explicitly lists partnering opportunities alongside proprietary assets.
| Program / service | Target / indication | Representative stage | Evidence & scope |
|---|---|---|---|
| p300 program | p300 · See individual trial / indication; not individually confirmed in this review | Preclinical | Human results not confirmed in this review |
| PVTX-321 | ER · See individual trial / indication; not individually confirmed in this review | Preclinical | Human results not confirmed in this review |
| PVTX-405 | IKZF2 · See individual trial / indication; not individually confirmed in this review | Preclinical | Human results not confirmed in this review |
Company-name matches are discovery leads; verify entity identity and transaction roles in the original source.
No cataloged update explicitly mentions this company.
Amphista announced an ASH oral presentation on AMX-883-mediated BRD9 degradation, describing disruption of hematopoietic transcriptional programs, myeloid differentiation, and reduced leukemic stem-cell frequency in experimental work. A separate abstract outlines the ongoing Phase 1 BRAMLIE study in AML and high-risk myelodysplastic syndrome. The announcement does not establish clinical efficacy for AMX-883.
Nurix announced updated Phase 1a/1b findings for its oral BTK degrader bexobrutideg (NX-5948) in relapsed or refractory CLL/SLL. The ASH presentation will include patients previously exposed to covalent BTK inhibitors and data at the recommended Phase 2 dose of 600 mg once daily. The release describes durable activity without providing numerical response rates.
A PNAS study reports RHV, a tetravalent bispecific protein designed to internalize and lysosomally degrade VCAM-1 and VEGFR on pathological vessels. The original abstract describes activity in mouse choroidal neovascularization models, including efficacy comparable to aflibercept at one-quarter of the molar dose. This is preclinical extracellular receptor degradation, distinct from an intracellular small-molecule PROTAC.
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