Pharmaceutical perspectives on oligonucleotide therapeutics and delivery systems
Dalton W Staller; Flobater I Gawargi; Sanjali S Panigrahi; Paras K Mishra; Ram I Mahato
Pharmacological Reviews ·
DOI: 10.1016/j.pharmr.2025.100065
First online May 14, 2025; July 2025 issue.
Research guide
This review examines RNA species, structure and function, chemical modifications, and delivery systems in the context of therapeutic development. It connects molecular design with stability and distribution and discusses clinical applications available at the time of writing. Its historical approval overview should not be interpreted as a current, exhaustive drug list.
Potential research relevance
Provides a framework for separating payload chemistry from delivery strategy.
Guide basis: Accessible article and abstract. No expert sign-off or citation count is claimed.