可裂解胆固醇交联稳定阴离子mRNA-LNP
Stabilizing Anionic mRNA Lipid Nanoparticles by Cleavable Crosslinking of Cholesterol
Yunhe Su; Joseph Choy; Xiang Liu; Yining Zhu; Jinghan Lin; Christine Wei; Kailei D. Goodier; Di Yu; Leonardo Cheng; Milan Patel; Xiaoya Lu; Jingyao Ma; Jialiang Wang; Hai-Quan Mao
ACS Applied Materials & Interfaces · DOI 10.1021/acsami.6c06888
酸敏可裂解胆固醇交联剂与PEG二胺稳定阴离子LNP，缓解纯化中重排及活性损失。调节交联结构可兼顾颗粒稳定与RNA释放，在动物中提高脾脏表达。
收录理由：扩展脾递送的阴离子配方空间；交联剂清除、重复给药及工艺可比性仍需评价。