Model-Informed Decision Making from Drug Discovery to Reimbursement: A Roadmap for Clinical Pharmacology in Value-Based Healthcare
Rajesh Krishna; Ananth Kadambi; Patrick Smith; Piet H van der Graaf; Fran Brown
The Journal of Clinical Pharmacology ·
DOI: 10.1002/jcph.70270
Research guide
This commentary proposes a lifecycle approach to model-informed decision-making, from discovery and dose selection to regulatory evaluation and reimbursement. It discusses quantitative methods, patient-relevant outcomes, and real-world data, alongside challenges in integration, transparency, and stakeholder acceptance. It is a conceptual roadmap, not a prospective validation of one modeling strategy.
Potential research relevance
Helps frame modeling around decisions and the evidence needed to support them.
Guide basis: Original journal abstract and bibliographic metadata. No expert sign-off or citation count is claimed.