Mass-spectrometry-based proteomics: from single cells to clinical applications

Research guide

This review surveys improvements in proteomics sample preparation, instrumentation, data acquisition, and analysis. It connects single-cell and spatial profiling with protein interactions, modifications, and biomarker discovery in body fluids. Clinical implementation is discussed as an opportunity with remaining challenges, rather than proof that every discovery assay is ready for diagnostic use.

Potential research relevance

A broad starting point for biomarker discovery and the distinction between research workflows and clinical implementation.

Guide basis: Original journal abstract and bibliographic metadata. No expert sign-off or citation count is claimed.