The official pipeline explicitly lists HJ-002 and HJ-004 as EGFR PROTACs for NSCLC and advanced cancers, respectively.
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Disease tags identify mentions in recorded facts or pipeline text, not approved indications or a complete pipeline. Platform service providers may have no disease-specific tag.
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The website lists NanoBRET/TR-FRET/SPR and HiBiT/JESS platforms for permeability, target engagement, ternary complexes, and quantitative degradation kinetics.
A dedicated page describes E1/E2/E3 and deubiquitinase assays for the ubiquitin–proteasome system, plus PROTAC evaluation from ternary complexes to degradation kinetics and selectivity.
Develops the LUNAR lipid delivery and STARR self-amplifying mRNA platforms. KOSTAIVE is an approved sa-mRNA COVID-19 vaccine.
Active in nucleic acid synthesis since 1996; a Maravai-owned CDMO supplying mRNA, NTPs, and CleanCap capping reagents.
CHARMED provides parallel synthesis with common E3 ligands and linkers, degradation screening, and early ADME. The website identifies an SHP2 degrader collaboration with Japan's UBE.
Founded in 2009, this LNP delivery technology company advances nucleic acid drug delivery R&D and commercialization primarily through partners. Licensed platforms are not classified as company-owned drug candidates.
An official technical poster describes development of bifunctional degraders using novel E3 ligases and construction of molecular glue libraries.
The group connects candidates with clinical and commercial supply through solid-state, preformulation, oral formulation development, and manufacturing services. Formulation execution entities include CFS and Candoo.
The website offers CRBN/VHL/IAP degrader design and synthesis, binary / ternary binding, NanoBRET, HiBiT, ubiquitination, and direct-to-biology workflows, and lists a collaboration with Amphista.
The company explicitly accepts FFS, cost-sharing, and FTE models. Its dedicated page lists validated assays for BRD4, KRAS, CRBN/VHL binding, and ternary complexes.
The website explicitly offers PROTAC and molecular glue screening and drug discovery support, describing assay systems for degradation research.
A dedicated R&D Systems page explicitly offers custom active-degrader design / synthesis, building-block panels, and E3 ligase development, including a Tocris client case.
CFS is a wholly owned Crystal Pharmatech subsidiary offering development, analysis, and clinical-to-commercial manufacturing of conventional and ASD oral dosage forms, with disclosed spray drying and hot-melt extrusion capabilities.
On 2026-08-13, FDA granted accelerated approval to iberdomide (Zenbexus) with daratumumab/hyaluronidase-fihj and dexamethasone for certain previously treated multiple myeloma patients. It is a CRBN-modulating CELMoD.
On 2026-06-08, Roche announced joint development and commercialization with Nurix of the oral BTK degrader bexobrutideg (NX-5948), with CLL Phase 3 planned for summer 2026.
Kymera's Q2 2026 update reports that Sanofi began first-in-human Phase 1 KT-485 (SAR447971), an oral IRAK4 degrader, in June. Sanofi is responsible for subsequent development, regulatory work, and commercialization.
DT2216 is a VHL-recruiting BCL-XL PROTAC. An original 2025 Phase 1 paper in 20 patients reports human PK and peripheral leukocyte BCL-XL reduction. NCI lists combination studies in ovarian and fibrolamellar liver cancers.
An original joint announcement with Photys on 2026-08-13 reports Phase 1 healthy-volunteer dosing of HPB-143/PHT-776. Polymed licensed development and commercialization rights outside Greater China and Southeast Asia to Photys.
An original Nurix announcement on 2026-09-29 reports a research milestone in the Pfizer DAC collaboration. Pfizer handles antibody conjugation and subsequent development. Global vepdegestrant development, manufacturing, and commercialization rights transferred to Rigel in June 2026.
Lilly's website lists LY4584180 as an oral, monovalent BCL6 polymerizing molecular glue. Phase 1 NOVA-BCL6-1, NCT07226843, is recruiting; UCSF's trial page records an April 2026 start.
A dedicated official page offers PROTAC and partial-PROTAC synthesis, E3 ligand / linker design, molecular glues, ternary-complex and cellular degradation evaluation, and custom ADME/PK and toxicology services, through standalone or integrated projects.
This Canadian formulation provider uses QbD approaches for oral dosage form development and manufacturing process design, including immediate-release, controlled-release, bilayer, orally disintegrating, and sublingual products.
The official custom synthesis page explicitly lists molecular glue libraries and bifunctional compounds including PROTACs, with FTE quotations and IP-sensitive work under confidentiality agreements.
Coverage expands from sourced records; this database does not claim all biopharma companies.